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The pathophysiological mechanisms underlying PCOS are closely associated with the dysfunction of the hypothalamic-pituitary-ovarian axis, hyperandrogenemia, insulin resistance, and adrenal endocrine disorders

People on certain medications are more prone to water retention, as are people with some kidney or heart problems

Clinical trial registration: www.irct.ir, Iranian Registry of Clinical Trials IRCT20080904001197N13

Estrogens, including E2, also promote hippocampal plasticity (5053) through several possible actions (54), including through its actions on spinogenesis (55), and inflammation in the hippocampus (56) in female rodents

The reason for the inconsistency is primarily the different models that have been used in the studies (patients, different animal species and strains, various cell models)